Uric acid yog ib qho khoom nruab nrab ntawm purine metabolism. Nws yog tsim los ntawm oxidation ntawm xanthine los ntawm xanthine oxidase. Nws yog ib hom oxypurine nrog antioxidant zog. Hauv cov tsiaj hauv av feem ntau, urate oxidase tuaj yeem ua rau cov oxidation ntxiv ntawm uric acid rau allantoin, tab sis urate oxidase noob ntawm tib neeg thiab qee cov primates siab heev tsis ua lub luag haujlwm, yog li uric acid yuav tsis raug ntxiv rau hauv lub cev. Yog vim li cas vim li cas qhov kev ua haujlwm ntawm urate oxidase poob rau hauv cov txheej txheem ntawm tib neeg evolution tseem yog ib lo lus nug uas yuav tsum tau tshawb nrhiav. Cov khoom antioxidant ntawm uric acid coj cov kws tshawb fawb los xav tias qhov kev hloov pauv no yuav muaj txiaj ntsig zoo rau cov primates thaum ntxov thiab tib neeg. Cov txiaj ntsig ntawm kev tshawb fawb txog kev hloov pauv ntawm cov kab mob mus rau qhov chaw siab siab txhawb nqa qhov kev xav tias uric acid ua antioxidant tuaj yeem txo cov kev ntxhov siab oxidative los ntawm qhov siab siab hypoxia. Hauv kev sim tsiaj ntawm cov kab mob tshwm sim los ntawm oxidative kev nyuaj siab, nws tau pom tias uric acid tuaj yeem tiv thaiv lossis txo cov kab mob. Cov kws tshawb fawb tau ntaus nqi nws rau cov khoom antioxidant ntawm uric acid. Cov kev tshawb fawb tau tshwm sim ntawm cov tshuaj tiv thaiv antioxidant ntawm uric acid kuj txhawb cov lus pom zoo no.
Rau ntau yam sclerosis, Gwen Scott piav qhia qhov tseem ceeb ntawm uric acid ua antioxidant rau ntau yam sclerosis. Cov theem ntawm uric acid nyob rau hauv cov ntshav yog inversely cuam tshuam rau qhov tshwm sim ntawm ntau yam sclerosis, vim hais tias cov ntshav ntawm ntau yam sclerosis cov neeg mob cov theem ntawm uric acid yog tsawg, thiab cov neeg mob gout tsis tshua muaj kev txom nyem los ntawm tus kab mob no. Qhov tseem ceeb tshaj, uric acid tuaj yeem siv los kho kev sim tshuaj tsis haum cerebrospinal kab mob-tus qauv tsiaj ntawm ntau yam sclerosis. Nyob rau hauv luv luv, txawm hais tias lub mechanism ntawm uric acid raws li ib tug antioxidant yog zoo txhawb, qhov kev thov hais tias cov theem ntawm uric acid nyob rau hauv lub cev muaj feem xyuam rau txoj kev pheej hmoo ntawm ntau yam sclerosis yog tseem muaj teeb meem thiab xav tau kev tshawb fawb ntxiv.
Uric acid muaj qhov siab tshaj plaws ntawm tag nrho cov ntshav antioxidants, thiab ib nrab ntawm tag nrho cov antioxidant muaj peev xwm nyob rau hauv tib neeg cov ntshav yog pab los ntawm nws. Kev ua haujlwm antioxidant ntawm uric acid yog qhov nyuaj heev. Nws tsis tuaj yeem hnov mob nrog qee cov oxidants xws li superoxide, tab sis nws tuaj yeem muaj cov nyhuv antioxidant ntawm peroxynitrite, peroxide thiab hypochlorous acid.
